PCR plate and master mix
Target List
ATM
The most commonly detected ATM loss-of-function mutations occur in the FAT, FATC and kinase domains.
CDKN2A
The most important CDKN2A loss-of-function mutations occur in the consensus ankyrin domain, which lead to the inability to form stable complexes with its targets.
RB1
The most recurrent loss-of-function mutations in the RB1 tumor suppressor gene either truncate the protein or disrupt interactions with its binding partners.
TP53
The most frequently detected somatic TP53 mutations occur in the DNA-binding domain which disrupt DNA binding and/or protein structure.